Romelu Lukaku returns to the XI to face Crystal Palace for his first start since the Champions League home match against Juventus four games ago.
The Belgian striker wasn't available to play for his country during the international break, after returning as a sub for United against City following a hamstring injury, but Mourinho has monitored his progress and names him to lead the line in the Premier League clash with Palace.
Luke Shaw picked up his fifth yellow card of the season in the derby a fortnight ago and is suspended so his place in the Reds' defence has gone to Matteo Darmian.